劉莊（蘇州大學納米科學技術學院教授）

人物經(jīng)歷

2008年至2009年在斯坦福大學化學系以及醫(yī)學院從事博士后研究。

2009年6月加入蘇州大學功能納米與軟物質(材料)實驗室，被聘為教授，博士生導師。

主要成就

研究方向

納米生物技術，癌癥分子影像與檢測，藥物輸送和癌癥治療。

代表論文

Chao Liang, Shuo Diao, Chao Wang, Hua Gong, Teng Liu, Guosong Hong, Xiaoze Shi, Hongjie Dai*, Zhuang Liu* “Tumor Metastasis Inhibition by Imaging-guided Photothermal Therapy with Single-walled Carbon Nanotubes”

Adv. Mater.

Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu*, “Multifunctional theranostic red blood cells for magnetic field enhanced in vivo combination therapy of cancer”

Adv. Mater.

Liang Cheng, Wenjing Huang, Qiufang Gong, Changhai Liu, Zhuang Liu*, Yanguang Li* and Hongjie Dai “Ultra-Thin WS2 Nanoflakes as a Highly Efficient Electrocatalyst for Hydrogen Evolution Reaction”

Angew. Chem. Int. Ed.

Adv. Mater.

Liang Cheng, Jingjing Liu, Xing Gu, Hua Gong, Xiaoze Shi, Teng Liu, Chao Wang, Xiaoyong Wang, Gang Liu, Huaiyong Xing, Wenbo Bu, Baoquan Sun,Zhuang Liu*“PEGylated WSnanosheets as a multifunctional theranostic agent for in vivo dual-modal CT / photoacoustic imaging guided photothermal therapy”

Adv. Mater.

Zhiwei Li, Shengnan Yin, Liang Cheng, Kai Yang, Yonggang Li,Zhuang Liu*“Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer”

Adv. Funct. Mater.

Xuejiao Song, Hua Gong, Shengnan Yin, Liang Cheng, Chao Wang, Zhiwei Li, Yonggang Li, Xiaoyong Wang, Gang Liu,Zhuang Liu* "Ultra-small Iron Oxide Doped Polypyrrole Nanoparticles for in vivo Multimodal Imaging Guided Photothermal Therapy"

Adv. Funct. Mater.

Hua Gong, Rui Peng*,Zhuang Liu*“Carbon nanotubes for biomedical imaging: The recent advances”

Adv. Drug Delivery Rev.

Kai Yang, Liangzhu Feng, Hao Hong, Weibo Cai,Zhuang Liu*. “Preparation and functionalization of graphene nanocomposites for biomedical applications”

Nature Protocols

Chao Wang, Huan Xu, Chao Liang, Yumeng Liu, Zhiwei Li, Guangbao Yang, Liang Cheng, Yonggang Li,Zhuang Liu* “Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect”

ACS Nano,

Chao Wang, Liang Cheng, Xinxing Ma, Xiaojing Wang, Yumeng Liu, Zhaoyi Deng, Yonggang Li,Zhuang Liu* “Imaging-guided pH Sensitive Photodynamic Therapy using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light”

Adv. Funct. Mater.

Liang Cheng, Chao Wang, Xinxing Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li,Zhuang Liu* “Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem Cell Therapy under Remote Magnetic Control”

Adv. Funct. Mater.

Kai Yang, Yingjie Li, Xiaofang Tan, Rui Peng*, Zhuang Liu* “Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems”

Small,

Kai Yang, Liangzhu Feng, Xiaoze Shi, Zhuang Liu* “Nano-graphene in biomedicine: theranostic applications”

Chem. Soc. Rev.

Liang Cheng, Chao Wang, Xinxing Ma, Qinglong Wang, Yao Cheng, Han Wang, Yonggang Li, Zhuang Liu* “Multifunctional Upconversion Nanoparticles for Dual-modal Imaging Guided Stem Cell Therapy under Remote Magnetic Control”

Adv. Funct. Mater

Kai Yang, Huan Xu, Liang Cheng, Chunyang Sun, Jun Wang, Zhuang Liu* “In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles”

Adv. Mater.

Liang Cheng, Kai Yang, Qian Chen, Zhuang Liu*, “Organic Stealth Nanoparticles for Highly Effective in Vivo Near-Infrared Photothermal Therapy of Cancer”

ACS Nano,

Xiaojing Wang, Chao Wang, Liang Cheng, Shuit-Tong Lee, Zhuang Liu* “Noble Metal Coated Single-walled Carbon Nanotubes for Applications in Surface Enhanced Raman Scattering Imaging and Photothermal Therapy”

J. Am. Chem. Soc.

Kai Yang, Lilei Hu, Xingxing Ma, Shuoqi Ye, Liang Cheng, Xiaoze Shi, Changhui Li, Yonggang Li, Zhuang Liu* “Multimodal imaging guided photothermal therapy using functionalized graphene nano-sheets anchored with magnetic nanoparticles”

Adv. Mater.

Chao Wang, Xinxing Ma, Shouqi Ye, Liang Guo, Changhui Li, Yonggang Li*, Zhuang Liu* “Protamine functionalized single-walled carbon nanotubes for stem cell labeling and in vivo Raman / magnetic resonance / photoacoustic triple-modal imaging”

Adv. Funct. Mater.

Bo Tian, Chao Wang, Shuai Zhang, Liangzhu Feng, Zhuang Liu* “Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide”

ACS Nano

Liang Cheng, Kai Yang, Yonggang Li, Jianhua Chen, Chao Wang, Mingwang Shao*, Shuit-Tong Lee, Zhuang Liu* “Facile preparation of multifunctional upconversion nanoprobes for multi-modal imaging and dual-targeted photothermal therapy”

Angew. Chem. Int. Ed

Kai Yang, Jianmei Wan, Shuai Zhang, Youjiu Zhang, Shuit-Tong Lee, Zhuang Liu* “In vivoPharmacokinetics, Long-Term Biodistribution, and Toxicology of PEGylated Graphene in Mice”

ACS Nano,

Chao Wang, Huiquan Tao, Liang Cheng, Zhuang Liu* “Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles”

Biomaterials,

Chao Wang, Liang Cheng, Zhuang Liu,* “Drug Delivery with Upconversion Nanoparticles for Multi-Functional Targeted Cancer Cell Imaging and Therapy”

Biomaterials,

Kai Yang, Shuai Zhang, Guoxin Zhang, Xiaoming Sun, Shuit-Tong Lee and Zhuang Liu,* “Graphene in Mice – Ultra-high in vivo Tumor Uptake and Highly Efficient Photothermal Therapy”

Nano Lett.

成果貢獻

近年來一直在納米醫(yī)學與腫瘤納米技術領域從事研究。

2005年以來發(fā)表學術論文100余篇，其中回國后獨立發(fā)表通信作者論文70余篇，相當一部分成果發(fā)表于Chem. Soc. Rev., Nature Protocols, Angew. Chem. Int. Ed., JACS, Adv. Mater., Ad. Funct. Mater. Nano Lett., ACS Nano等國際權威刊物上。

全部論文總引用已超過11,000次，SCI H-index為48。獲國家自然科學基金委優(yōu)秀青年基金資助，江蘇省杰出青年基金資助；作為課題負責人承擔科技部973項目課題一項。

當前研究興趣包括納米材料的生物學效應與生物安全性研究；基于碳納米材料的生物成像、藥物輸送和治療治療研究；稀土上轉換發(fā)光納米材料在生物傳感、生物成像、以及癌癥治療上的應用；新型多功能復合納米材料的開發(fā)及其在多模態(tài)癌癥成像與治療上的應用；基于有機高分子納米材料的腫瘤光學治療與聯(lián)合治療；以及基于納米技術的干細胞研究和細胞療法研究等。

應國際著名期刊Biomaterials主編、美國工程院院士Kam W. Leong教授邀請，劉莊教授出任Biomaterials雜志新一屆副主編。劉莊教授是該期刊新一屆編委中唯一一位來自中國大陸的副主編。

2021年8月，蘇州大學功能納米與軟物質研究院教授劉莊、陳倩以及上海市肺科醫(yī)院教授楊洋團隊合作，開發(fā)了一種可吸入的含人血管緊張素轉化酶2（hACE2）的納米捕獲劑。該藥物能與人體內的宿主細胞競爭結合SARS-CoV-2，由此保護人體宿主細胞免受感染。該成果發(fā)表于美國《國家科學院院刊》。^[2]

獲得榮譽