鄭忠亮（武漢大學(xué)生命科學(xué)學(xué)院副教授）

正文

教育經(jīng)歷：

1995年－1999年，湖北工業(yè)大學(xué)，發(fā)酵工程系，本科/學(xué)士

2000年－2005年，武漢大學(xué)，生命科學(xué)學(xué)院/生化與分子生物學(xué)系，研究生/碩博連讀

工作經(jīng)歷：

2005年－2012年，武漢大學(xué)生命科學(xué)學(xué)院/生化與分子生物學(xué)系，講師

2005年－至今，武漢大學(xué)生命科學(xué)學(xué)院/生化與分子生物學(xué)系，副教授

2008年3月－2011年7月，美國匹茲堡大學(xué)醫(yī)學(xué)院病理系，博士后

教學(xué)工作：

2005年－至今，主講本科選修課《酶工程》

2011年－至今，主講研究生選修課《高級分子生物學(xué)及生物化學(xué)》

主持課題：

國家自然科學(xué)基金項目《腺病毒介導(dǎo)精氨酸脫亞氨基酶靶向性基因治療肝癌的機制》，(2014.01-2017.12),(NO. 81372441).

國家自然科學(xué)基金項目《精氨酸脫亞氨基酶催化機理及結(jié)構(gòu)與功能的研究》，(2009.01-2011.12),(NO. 30800190).

湖北省自然科學(xué)基金項目《新型可口服微生物溶血栓藥物的分子結(jié)構(gòu)的設(shè)計與改造》(2007.01-2009.12)年.

湖北省攻關(guān)項目《液態(tài)深層發(fā)酵法生產(chǎn)番茄紅素的中試研究》（2007.01-2009.12）.

研究方向：

1、中國人手足口病病毒（EV71）侵染人體的細(xì)胞途徑和病理機制。主要解決EV71經(jīng)口腔進(jìn)入人體腸道后，通過什么樣的細(xì)胞機制和體液機制實現(xiàn)增殖、轉(zhuǎn)運及潛伏的科學(xué)問題。

2、抗腫瘤藥物在癌癥細(xì)胞信號傳導(dǎo)過程中的作用。主要利用腺病毒、慢病毒等載體介導(dǎo)抗腫瘤基因靶向性治療癌癥的分子機制的科學(xué)問題。

3、蛋白產(chǎn)品及免疫型診斷試劑的開發(fā)

代表性論文:

1. Jieyuan Wu, W. c., Yan Yin, Zhongliang Zheng*, Guolin Zou (2014). "Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex." Biometals: Published online.

2.Yu-Chen Han, Zhong-Liang Zheng (co-author), Yan-Ping. Yu, Rui Chen, George C. Tseng, Joel B. Nelson and Jian-Hua Luo (2013). "Metallothionein 1h Tumor Suppressor Activity in Prostate Cancer Is Mediated By Euchromatin Methyltransferase 1." The Journal of Pathology

230

3.Zhongliang Zheng, LangZhu Tan, Yan P. Yu, George Michalopoulos, Jianhua Luo (2012). "Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell death." America Journal of Pathology

181

4.Michael Nalesnik, George Tseng, George Michalopoulos, Guo-Sheng Xiang, Zhong-liang Zheng, Yanping Yu and Jianhua Luo. (2012). "Gene Deletions and Amplifications in Human Hepatocellular Carcinomas: Correlation with Hepatocyte Growth Regulation." America Journal of Pathology

180

5.Hanjing Ding, Hui Liu, Y an Yin, Ying Ding, Yan Jia, Qingming Chen, Guolin Zou* and Zhongliang Zheng* (2012). "Insights into the modulation of optimum pH by a single histidine residue in arginine deiminase fromPseudomonas aeruginosa." Biol. Chem.

393

6.Ze-Hua Zhu, Yan-P. Yu, Zhong-Liang Zheng, Yang Song, Guo-Sheng Xiang, Joel Nelson, George Michalopoulos, Jian-Hua Luo. (2010). "Integrin Alpha 7 Interacts with High Temperature Requirement A2 (HtrA2) to Induce Prostate Cancer Cell Death." American Journal of Pathology.

177

7.Yan Jia, Hui Liu, Wei Bao, Meizhi Weng, Wei Chen, Yongjun Cai, Zhongliang Zheng, Guolin Zou. (2010). "Functional analysis of propeptide as an intramolecular chaperone for in vivo folding of subtilisin nattokinase." FEBS Letters

584

8.MeiZhi Weng, ZhongLiang Zheng, Wei Bao, YongJun Cai, Yan Yin, GouLin Zou. (2009). "Enhancement of oxidative stability of the subtilisin nattokinase by site-directed mutagenesis expressed in Escherichia coli." Biochimica et Biophysica Acta

1794

9.Jinsong Wang, Zhongliang Zheng, Jing Lei, Jicheng Pan, Guolin Zou. (2009). "Cloning, expression, characterization and phylogenetic analysis ofarginine kinase from greasyback shrimp (Metapenaeus ensis)." Comparative biochemistry and physiology, part B

153

10.HanDong Fan, Jing Liu, WenDan Ren, ZhongLiang Zheng, YuYing Zhang, Xi Yang, HuaPing Li, XiaoYan Wang, GuoLin Zou (2008). "pH Induces Thermal Unfolding of UTI: An Implication of Reversible and Irreversible Mechanism Based on the Analysis of Thermal Stability, Thermodynamic, Conformational Characterization." J Fluoresc

18

11.Zhenyu Zuo, Zhongliang Zheng, Zhigang Liu, Qingming Yi, Guolin Zou* (2007). "Cloning, DNA shuffling and expression of serine hydroxymethyltransferase gene from Escherichia coli strain AB90054." Enzyme and Microbial Technology

40

12.Xiwen Li, Zhongliang Zheng, Mingyue Han, Zhangping Chen, Guolin Zou* (2007). "Tuning J-Aggregates of Tetra(p-hydroxyphenyl)porphyrin by the Headgroups of Ionic Surfactants in Acidic Nonionic Micellar Solution." J. Phys. Chem. B

111

13.Zhongliang Zheng, Maoqing Ye, Zhenyu Zuo, Zhigang Liu, Kengchang Tsai, Guolin Zou. (2006). "Probing the Importance of Hydrogen Bonds around the Active Center of Nattokinase by Site-directed Mutagenesis and Molecular Dynamics Simulation." Biochemical J.

395

14.Zhigang Liu, Zhongliang Zheng, Zhenyu Zuo, Yingliang Wu, Aifu Liu, Qingming Yi, Wenxin Li. (2006). "Probing the Catalytic Center of Porcine Aminoacylase 1 by Site-Directed Mutagenesis, Homology Modeling and Substrate Docking." J Biochem (Tokyo).

139

15.Zhongliang Zheng, Zhenyu Zuo, Zhigang Liu, Kengchang Tsai, Aifu Liu,1, Guolin Zou (2005). "Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto—A novel nucleaphilic catalytic mechanism for nattokinase." J. Mo.l Graph. Mod.

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