曹春陽（上海有機(jī)化學(xué)研究所“百人計(jì)劃”研究員）

研究方向

1）利用核磁共振（NMR）技術(shù)研究若干生物大分子溶液三維結(jié)構(gòu)、動(dòng)力學(xué)與功能關(guān)系。

曹春陽[上海有機(jī)化學(xué)研究所“百人計(jì)劃”研究員]

3）利用化學(xué)結(jié)構(gòu)修飾（有機(jī)合成）與酶學(xué)方法研究與疾病相關(guān)的酶與底物相互作用機(jī)制。4）利用定點(diǎn)突變技術(shù)研究重要氨基酸及有關(guān)氨基酸側(cè)鏈在酶生物催化過程中的作用。

5）基于生物大分子溶液三維結(jié)構(gòu)及相關(guān)酶生物催化機(jī)制, 利用有機(jī)合成方法進(jìn)行抗腫瘤藥物分子、其它藥物分 子合理化設(shè)計(jì)。

代表論著

1.Lan WX, Wang ZH, Yang ZZ, Cao C*. et alConformational toggling of Yeast Iso-1-cytochrome c in the oxidized and reducedstates, PLoS One, 2011, accepted

2.Zhu S, Peigneur S, Gao B, Lu X, Cao C*,Tytgat J. Evolutionary diversification of Mesobuthus {alpha}-scorpion toxinsaffecting sodium channels, Mol Cell Proteomics, 2011,in press

3.Zhang Y., Hu W., Shen J., Tong XT, LanWX, Cao C*. Cys397 plays important roles in the global folding of theneuron-restricted silencer factor/RE1-silencing transcription factor, BBRC,2011, in press

4.Zhang LL, Yang Z., Zhang Y., Cao C*., etal Highly efficient production of soluble proteins from insoluble inclusionbodies by a two-step-denaturing and refolding method PloS One 2011,2011;6(7):e22981.

5.Wang CK, Shen J., Yang ZZ, Cao C*. et alStructural basis of readout of unmodified H3R2 by UHRF1 PHD, Cell Res, 2011,2011, 21(9):1379-82

6.Tong XT, Lan WX, Zhang X., Liu ML, CaoC*., Solution structure of all parallel G-quadruplex formed by the oncogene RETpromoter sequence Nucleic Acid Res. 2011, 2011 39(15):6753-63

7.中國(guó)專利申請(qǐng), Cao C*., etal Synthesis of the derivative of 4-(2,4,6- trimethylphenoxy) -5-fulorouraci,2010, Application code 201010611826.3

8.中國(guó)專利申請(qǐng), Cao C*., etal， An novel approach to real-time detect deamination of cytosinecontained in HIV-1 cDNA, 2010, Application code 201010611814.0

9.Zhu, J; Tong, XT; Cao, C; Wu, G; Zhang,N; Wu, H. Solution structure of BmK? Tx11, a toxin from the venom of theChinese scorpion Buthus martensii Karsch. BBRC (2010), 391(1), 627-633.

10.Ju, J; Yang, ZZ; Wu, HM; Wang, ZF; Cao,C*. Solution structure determination of zinc finger 9 in NRSF/REST by NMR.Huaxue Xuebao (2009), 67(7), 705-708.

11.Guan, W; Liu, YH; Shen, Jie; Tang, PP;Wu, HM; Zhang, GA; Cao, C*.. DNA: a biological target of 23-Oxa-OSW-1? HuaxueXuebao (2008), 66(14), 1745-1748.

12.Sheng, Z.-Z.; Wang, ZQ; Wu, HM; Huang,ZX; Wu, XX; Cao, C*. 1H NMR studies on heme microenvironment of cytochrome b5mutant P40V. Huaxue Xuebao (2008), 66(10), 1221-1227.

13.Tong, XT; Zhu, J; Ma, Y; Chen, X; Wu, G;He, F; Cao, C.; Wu, HM. Solution Structure of BmK? IT01, an -Insect Toxin fromthe Venom of the Chinese Scorpion Buthus martensii Karsch. Biochem (2007),46(40), 11322-11330.

14.Cao C, Jiang Y.L., Krosky D, StiversJT. “The Catalytic Power of Uracil DNAGlycosylase in the Opening of Thymine Base Pairs” J. Am. Chem. Soc., 2006, 128(40), 13034-13035.

15.Cao C, Stivers JT “Dynamic opening ofnormal thymidine bases during enzymatic search for damaged sites in DNA” NatureStructural and Molecular Biology 2004, 11(12), 1230-1236

16.Cao C, Kwon K, Jiang YL, Drohat A,Stivers JT “Solution structure and base perturbation studies reveal a novelmode of alkylated base recognition by 3-methyladenine DNA glycosylase I” TheJournal of Biological Chemistry 2003, 278(48), 48012-48020.

17.Cao C, Wu HM, Xue L, Wang Y, Huang ZX;“The solution structure of the oxidized bovine microsomal cytochrome b5 mutantV61H” BBRC, 2003, 307(3), 600-609.

18.Cao C, Wang Y, Wu HM, Wang ZQ, Wang Y,Huang ZX “NMR study of the effect oncytochrome b5 heme caused by the mutation in the residue Val45” Biochimie 2003, 85(10), 1007-1016.