柳紅（中國(guó)科學(xué)院上海藥物研究所博導(dǎo)）

人物經(jīng)歷

1991.9.1-1993.8.31，山東新華制藥廠四車間，助理工程師。

1999.8.1-2001.8.31，中國(guó)科學(xué)院上海藥物研究所，博士。

2002.2.1-2002.10.30，美國(guó)University of Texas Medical Branch 大學(xué)，訪問科學(xué)家（Visiting Scientist）。

2005.1.1-2005.10.30，美國(guó)University of Texas Medical Branch 大學(xué)，訪問科學(xué)家（Visiting Scientist）。

2001.9.1-2006.6.30，中國(guó)科學(xué)院上海藥物研究所，副研究員、碩士生導(dǎo)師。

2006.1.7-至今，中國(guó)科學(xué)院上海藥物研究所，研究員、博士生導(dǎo)師^[1]。

曾擔(dān)任中國(guó)藥學(xué)會(huì)藥物化學(xué)專業(yè)委員會(huì)委員、上海藥學(xué)會(huì)藥物化學(xué)專業(yè)委員會(huì)委員、上海市婦聯(lián)婦代會(huì)執(zhí)委委員等，任藥學(xué)學(xué)報(bào)、中國(guó)藥物化學(xué)雜志編委會(huì)成員;^[4]

主要成就

1.發(fā)展高效的合成方法學(xué)構(gòu)建類藥性(手性)雜環(huán)化合物庫

2.針對(duì)重大疾病的創(chuàng)新藥物研究

（1）抗糖尿病藥物DPPIV抑制劑的發(fā)現(xiàn)研究

（2）抗老年癡呆藥物的發(fā)現(xiàn)研究

（3）靶向α1A-AR的新型抗前列腺增生藥物的發(fā)現(xiàn)研究

（4）抗腫瘤藥物c-Met抑制劑的發(fā)現(xiàn)研究

（5）抗HIV藥物CCR5抑制劑的發(fā)現(xiàn)研究^[1]

承擔(dān)科研項(xiàng)目情況

1.國(guó)家自然科學(xué)基金重大研究計(jì)劃重點(diǎn)支持項(xiàng)目，S1P在腫瘤細(xì)胞糖脂代謝異常及非可控性炎癥向腫瘤癌轉(zhuǎn)化中的分子調(diào)控，項(xiàng)目負(fù)責(zé)人，2013.01-2016.12

2.國(guó)家科技十二五重大專項(xiàng)，抗糖尿病類LJN系列新藥候選物的臨床前研究，項(xiàng)目負(fù)責(zé)人，2012.01-2015.12

3.上海市優(yōu)秀學(xué)術(shù)帶頭人計(jì)劃，手性藥物優(yōu)勢(shì)骨架化合物庫的構(gòu)建與新藥設(shè)計(jì)與發(fā)現(xiàn)研究，項(xiàng)目負(fù)責(zé)人，2012.07-2014.06

4.國(guó)家杰出青年基金，藥物化學(xué)，項(xiàng)目負(fù)責(zé)人，2011.01-2014.12

5.歐盟F7框架計(jì)劃SILVER項(xiàng)目，Small-molecule inhibitor leads versus emerging and neglected RNA viruses，中方負(fù)責(zé)人，2010.10-2014.09

6.科技部對(duì)歐盟合作項(xiàng)目，抗腸道病毒（EV68、EV71）小分子抑制劑研究，項(xiàng)目負(fù)責(zé)人，2011.12-2013.12

7.國(guó)家高技術(shù)研究發(fā)展計(jì)劃（863）基金JG3，DC06及DC032的研究與開發(fā)，項(xiàng)目負(fù)責(zé)人，2006.11-2010.12

8.國(guó)家自然科學(xué)基金項(xiàng)目，新型鉀離子通道阻滯劑的發(fā)現(xiàn)及其亞型的選擇性和功能研究，項(xiàng)目負(fù)責(zé)人，2008.1-2011.12^[1]

研究領(lǐng)域

主要從事藥物化學(xué)基礎(chǔ)和應(yīng)用基礎(chǔ)的研究工作，研究領(lǐng)域涉及藥物化學(xué)、有機(jī)合成和計(jì)算機(jī)輔助藥物設(shè)計(jì)等學(xué)科。作為課題負(fù)責(zé)人先后承擔(dān)了國(guó)家高技術(shù)“863”計(jì)劃、國(guó)家自然科學(xué)基金、上海市科委等基金項(xiàng)目。近年來，圍繞新結(jié)構(gòu)類型先導(dǎo)化合物的合成，開展新的有機(jī)合成方法學(xué)研究，在Chemistry & Biology、Journal of Biological Chemistry、Journal of Medicinal Chemistry、Organic Letters、 Journal of Organic Chemistry、Journal of Combinatorial Chemistry、Biophysical Journal、Journal of Pharmacology Experimental Therapeutics、Current Medicinal Chemistry、Bioorganic & Medicinal Chemistry、Tetrahedron Letters和Drug Metabolism and Disposition等雜志上發(fā)表國(guó)內(nèi)外論文百余篇。參加5本專著的編寫，申請(qǐng)專利30項(xiàng)，獲得專利證書5項(xiàng)。

代表論著

1. Shengbin Zhou, Jiang Wang, Xia Chen, José Luis Ace?a Vadim A. Soloshonok,* and Hong Liu*. Chemical Kinetic Resolution of Unprotected b-Substituted-b-Amino Acids Using Recyclable Chiral Ligands. Angewandte Chemie. 2014, 53, 7883-7886. (IF=13.734).

2. Jiang Wang, José Luis Ace?a, Santos Fustero, Carlos del Pozo, María Sánchez-Roselló, Vadim A. Soloshonok,* Alexander E. Sorochinsky, , Hong Liu*. Fluorine in Pharmaceutical Industry; Fluorinated Drugs Introduced to the Market in the Last Decade. Chemical Reviews. 2014,114, 2432?2506. (IF=41.298)

3. Wei Yang, Liliang Huang, Hong Liu, Wei Wang* and Hao Li*. Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines. Chem Comm 2013, 49, 4667-4669. (IF=6.378)

4. Enguang Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li, Deju Ye, Jiang Wang, Jian-Ping Zuo, Kyoung Tai No, Mingyue Zheng, Weiliang Zhu, * Wei Tang, * Baik-Lin Seong,* Hualiang Jiang, and Hong Liu* Structure-Based Design, Synthesis of C-1 and C-4 modified analogs of zanamivir as neuraminidase inhibitors. Journal of Medicinal Chemistry 2013, 56, 671-684. (IF=5.614)

5. Jiahui Wu, Dengyou Zhang, Lei Chen, Jianneng Li, Jianling Wang, Chengqing Ning,Niefang Yu, Fei Zhao,Dongying Chen,Xiaoyan Chen,Kaixian Chen, Hualiang Jiang, Hong Liu*,and Dongxiang Liu*, Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate Journal of Medicinal Chemistry 2013, 56,761-780. (IF=5.614)

6. Shengtao Xu, Yu Zhou, Jinyi Xu*, Hualiang Jiang, and Hong Liu* Gold-catalyzed Michael Addition/Intramolecular Annulation Cascade: an Effective Pathway for the Chemoselective- and Regioselective Synthesis of Tetracyclic Indole Derivatives in Water Green Chemistry. 2013,15,718-726. (IF=6.828)

7. Lei Zhang, Fei Zhao, Mingyue Zheng, Yun Zhai and Hong Liu* Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating Chem Comm 2013,49,2894-2896. (IF=6.378)

8. Daizong Lin, Jiang Wang, Xu Zhang, Shengbin Zhou, Jie Lian, Hualiang Jiang and Hong Liu* Highly diastereoselective synthesis of 3-indolylglycines Chem Comm 2013,49,2575-2577. (IF=6.378)

9. Jinfang Wang, Yu Zhou,* Lei Zhang, Zeng Li, Xianjie Chen and Hong Liu*. Asymmetric Michael Addition of N-tert-Butanesulfinyl Imidates: an Efficient Strategy for the Synthesis of (R)-3-Substituted Indanone Derivertives. Organic Letters. 2013,15,1508-1511. (IF=6.142)

10. Xianjie Chen , Hui Chen, Xun Ji, Hualiang Jiang, Zhu-Jun Yao, and Hong Liu*. Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthesis of Spiro [pyrrolidin-3, 2′-oxindole] Derivatives Organic Letters. 2013,15,1846-1849. (IF=6.142)

11. Enguang Feng, Yu Zhou, Fei Zhao, Xianjie Chen, Lei Zhang, Hualiang Jiang, Hong Liu* Gold-catalyzed tandem reaction in water: An efficient and convenient synthesis of fused polycyclic indoles. Green Chemistry. 2012, 14, 1888-1895. (IF=6.828)

12. Xianjie Chen, Wei Zhu, Wangke Qian, Enguang Feng, Yu Zhou, Jinfang Wang, Hualiang Jiang, Zhu-Jun Yao,* and Hong Liu.* Highly Enantioselective of 2-Oxindoles-3-carboxylate Ester to Nitroole?ns Promoted by Cinchona Alkaloid Thiourea-Br?nsted Acid Co-catalysts. Advanced Synthesis & Catalysis 2012, 354, 2151-2156. (IF=5.353)

13. Wangke Qian, Lei Zhang, Haifeng Sun, Hualiang Jiang, and Hong Liu* Microwave-assisted One-step Synthesis of Acetophenones via Palladium-catalyzed Regioselective Arylation of Vinyloxy-trimethylsilane Advanced Synthesis & Catalysis 2012, 354, 3231-3236. (IF=5.535)

14. Qian Ba, Miao Hao, He Huang, Junmei Hou, Shichao Ge, Zhuzhen Zhang, Jun Yin, Ruiai Chu, Liang Hua Jiang, Fudi Wang, Kaixian Chen, Hong Liu*, and Hui Wang* . Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin. Cancer Res. 2011, 17, 7625-7633. (IF=7.837)

15. Jiang Wang, Shengbin Zhou, Daizong Lin, Xiao Ding, Hualiang Jiang and Hong Liu*. Highly diastereo- and enantioselective synthesis of syn-β-substituted tryptophans via asymmetric Michael addition of a chiral equivalent of nucleophilic glycine and sulfonylindoles. Chem. Commun. 2011, 47, 8355-8357. (IF=6.378)

16. Haifeng Sun, He Huang, Dengyou Zhang, Enguang Feng, Wangke Qian, Lei Zhang, Kaixian Chen and Hong Liu*. Synthesis of 4-Aryl-2(5H)-furanones by Gold(I)-Catalyzed Intramolecular Annulation. Adv. Synth. Catal. 2011, 353, 1413-1419. (IF=5.535)

17. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang and Hong Liu*. An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization. Adv. Synth. Catal. 2011, 353, 1429-1437. (IF=5.535)

18. Diliang Guo, Tao Chen, Deju Ye, Jinyi Xu, Hualiang Jiang, Kaixian Chen, Hui Wang*, and Hong Liu*. Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria. Org. Lett. 2011, 13, 2884-2887. (IF=6.142)

19. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang and Hong Liu*. Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles. Green Chem. 2011, 3, 397-405. (IF=6.828)

20. Jin-gui Ma, He Huang, Ling-hua Meng, Si-meng Chen, Yi Chen, Xian-liang Xin, Li-ping Lin , Hong Liu*, Jian Ding,* PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo. Breast Cancer Research and Treatment. 2011, 130, 85-96. (IF=4.564)

21. Jing Deng , Enguang Feng, Sheng Ma, Yan Zhang, Xiaofeng Liu, Honglin Li*, Huang Huang, Jin Zhu, Weiliang Zhu, Xu Shen, Liyan Miao*, Hong Liu, Hualiang Jiang, Jian Li*. Design and Synthesis of First-in-Class Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases? Journal of Medicinal Chemistry.2011, 54, 4508-4522. (IF=5.614)

22. Yu Zhou, Chunyi Jiang, Yaping Zhang, Zhongjie Liang, Wenfeng Liu, Liefeng Wang, Cheng Luo, Tingting Zhong, Yi Sun, Linxiang Zhao, Xin Xie, Hualiang Jiang, Naiming Zhou,* Dongxiang Liu* and Hong Liu*. Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as β-Amyloid Peptide Aggregation Inhibitors. Journal of Medicinal Chemistry 2010, 53, 5449-5466. (IF=5.614)

23. Yu Zhou,Yun Zhai, Jian Li, Deju Ye, Hualiang Jiang and Hong Liu.* Metal-free Tandem Reaction in Water: An Efficient and Regioselective Synthesis of 3-Hydroxyisoindolin-1-ones. Green Chemistry. 2010, 12，1397-1404. (IF=6.828).

24. He Huang, Qin Chen，Xin Ku, Linghua Meng*, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding , Hong Liu.* A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity. Journal of Medicinal Chemistry 2010, 53, 3048-3064. (IF=5.614)

25. Yu Feng, Xiao Ding, Tao Chen, Lili Chen , Fang Liu, Xu Jia, Xiaomin Luo,Xu Shen, Kaixian Chen, Hualiang Jiang, Hui Wang*, Hong Liu*, Dongxiang Liu.* Design, Synthesis and Interaction Study of Quinazoline-2(1H)-Thione Derivatives as Novel Bcl-xL Inhibitors. Journal of Medicinal Chemistry 2010, 53, 3465-3479. (IF=5.614)^[1]

獲得榮譽(yù)