胡立宏（胡立宏）

人物簡介

同年九月赴新加坡國立大學(xué)化學(xué)系做博士后研究。1999年10月回國，應(yīng)聘為上海藥物所副研究員, 2002年起任中科院上海藥物所研究員、博士生導(dǎo)師。2002年4月至10月應(yīng)邀在美國聯(lián)邦食品和藥品管理局(FDA)下屬的毒理研究中心作訪問研究。主持、參與多項國家和上海市的重大基礎(chǔ)科學(xué)研究項目，至今已在國內(nèi)外著名專業(yè)雜志上發(fā)表SCI論文40多篇，申請專利5項，已發(fā)現(xiàn)了一批很有希望的苗子化合物。2001年獲上海市青年科技啟明星計劃，2002和2004年獲國家自然科學(xué)基金資助。

研究方向

活性天然化合物的發(fā)現(xiàn)及結(jié)構(gòu)優(yōu)化

獲獎成果

作為第六獲獎人的“現(xiàn)代新藥篩選體系和高通量篩選技術(shù)的研究及應(yīng)用”項目獲國家2003年度科學(xué)技術(shù)進步二等獎；作為第六獲獎人的“現(xiàn)代新藥篩選體系和高通量篩選技術(shù)的研究及應(yīng)用”項目獲上海市2002年度科學(xué)技術(shù)進步一等獎。

承擔(dān)科研項目情況

項目來源：國家杰出青年科學(xué)基金項目

項目名稱：天然藥物化學(xué)

承擔(dān)類別：項目負責(zé)人

項目來源：國家重大新藥創(chuàng)制

項目名稱：新長春堿類抗腫瘤藥物候選物F-XA7的臨床前研究

承擔(dān)類別：項目負責(zé)人

項目來源：科技部863

項目名稱：選擇性Beta-分泌酶天然抑制劑HL0362結(jié)構(gòu)優(yōu)化及抗AD藥物侯選物的發(fā)現(xiàn)

承擔(dān)類別：項目負責(zé)人

項目來源：國家自然科學(xué)基金項目

項目名稱：以活性小分子為探針的葡萄糖轉(zhuǎn)運蛋白GLUT4信號轉(zhuǎn)導(dǎo)通路探索及基于通路的抗II型糖尿病藥物先導(dǎo)結(jié)構(gòu)的發(fā)現(xiàn)

承擔(dān)類別：主要參加者

項目來源：國家自然科學(xué)基金項目

項目名稱：長春堿新衍生物的合成及其抗腫瘤構(gòu)效關(guān)系研究

承擔(dān)類別：項目負責(zé)人

代表論著

Xubing Chen, Jingjing Zhuang, Junhua Liu, LeiMin, Lei Ma, Jing Chen, Xu Shen, Lihong Hu*. Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle. Bioorganic & Medicinal Chemistry

Xuan Tang, Jingjing Zhuang, Jing Chen, Liang Yu, Lihong Hu*, Hualiang Jiang, Xu Shen*. Arctigenin efficiently enhanced sedentary mice treadmill endurance. PLoS ONE

Guiping Zhang, Sida Shen, Min Lei, Lihong Hu*, A facile and efficient method for the synthesis of solasodine from diosgenin. Tetrahedron

Haitao Zhang, Rong Zhou, Li Li, Jing Chen, Lili Chen, Chenjing Li, Hong Ding, Liang Yu, Lihong Hu*, Hualiang Jiang, Xu Shen*. Danthron functions as an RXR antagonist by stabilizing the receptor’s tetramers. Journal of Biological Chemistr

Lirui Wang, Xu Wang, Jing Chen, Zhengyi Yang, Liang Yu, Lihong Hu*, Xu Shen*. Activation of protein serine/threonine phosphatase PP2C? efficiently prevents liver fibrosis. PLoS ONE

Zhe Cheng, Anfeng Chen, Fang Wu, Li Sheng, Hankun Zhang, Min Gu, Yuanyuan Li, Lina Zhang, Li-Hong Hu*, Jingya Li*, Jia Li*. 8,8-Dimethylhydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models. Bioorganic & Medicinal Chemistry

Zhiyuan Zhu, Chenjing Li, Xu Wang, Zhengyi Yang, Jing Chen, Lihong Hu*, Hualiang Jiang, Xu Shen*. 2,2’,4’-Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory imparment in mice. Journal of Neurochemistry

Jiqing Xu, QiangShen, Jia Li*, Lihong Hu*. Dammarane from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphalatase 1B. Bioorganic & Medicinal Chemistry

Xiachang Wang, Zongping Zheng, Xianwen Gan, Lihong Hu*. Jatrophalactam, a novel diterpenoid lactam isolated from Jatropha curcas. Organic Letters

Yong Shao, Hankun Zhang, Hong Ding, Haitian Quan, Liguang Lou, and Lihong Hu*. Synthesis and structure-activity relationship studies of cytotoxic anhydrovinblastine amide derivatives, Journal of Natural Products,

Xianwen Gan, Wei Jiang, Wei Wang*, Lihong Hu*. An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. Three-step synthesis of leucomelone. Organic Letters

Guiping Zhang, Zhiyong Xiao, Jamal Rafique, Mohammad Arfan*, Peter J. Smith, Carmen A. Lategan, Lihong Hu*. Antiplasmodial isoflavavones from the roots of Sophora mollis. Journal of Natural Products

Hankun Zhang, Yong Shao, Hong Ding, and Lihong Hu*. Synthesis and Structure?Activity Relationship Studies of Cytotoxic Ester and Ether Anhydrovinblastine Derivatives, Journal of Natural Products

Yinan Zhang, Wei Zhang, Di Hong, Lei Shi, Qiang Shen, Jingya Li, Jia Li* and Lihong Hu*. Oleanolic Acid and Its Derivatives: New Inhibitor of Protein tyrosine Phosphatase 1B with Cellular Activities, Bioorganic Medicinal Chemistry,

Yinan Zhang, Shilei Zhang, Lei Ma, Xu Shen*, Wei Wang* and Lihong Hu*. Total Synthesis of (+)-Rutamarin, Advanced Synthesis & Catalysis

Zhonghui Lin, Yu Zhang, Yinan Zhang, Hong Shen, Lihong Hu*, Huangliang Jiang, and Xu Shen*. Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism, Biochemical Pharmacology

Nigel Turner, Jingya Li, Alison Gosby, Sabrina W. C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Lihong Hu*, Jia Li*, Jiming Ye*. Berberine, and its more Biologically Available Derivative Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMPK and Improve Insulin Action. Diabetes

Yong Shao, Hong Ding, Weidong Tang, Liguang Lou and Lihong Hu*. Synthesis and structure–activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues. Bioorganic & Medicinal Chemistry,

Yinan Zhang, Xianggen Zhong, Zongping Zheng, Xudong Hu, Jianping Zuo,* Lihong Hu*. Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. Bioorganic & Medicinal Chemistr

Lei Ma, Mumtaz Ali, Mohammad Arfan, Liguang Lou, Lihong Hu*. Withaphysanolide A, a Novel Carbon 27 Norwithanolide Skeleton, and Other Cytotoxic Compounds from Physalis divericata. Tetrahedron Letters