個(gè)人簡介
朱建華,作為主持人承擔(dān)了1項(xiàng)國家自然科學(xué)基金課題、1項(xiàng)廣州市珠江科技新星項(xiàng)目、1項(xiàng)省自然科學(xué)基金課題、1項(xiàng)中醫(yī)藥局科研項(xiàng)目以及2項(xiàng)暨南大學(xué)創(chuàng)新與培育基金課題的研究;作為第二申請人承擔(dān)了1項(xiàng)廣州市科技重大專項(xiàng)、作為第三申請人承擔(dān)了2項(xiàng)國家自然科學(xué)基金課題、作為子課題負(fù)責(zé)人承擔(dān)了2項(xiàng)國家科技重大專項(xiàng)課題的研究工作。目前,已在?Process Biochemistry?、?Fitoterapia?、?ChineseChemicalLetters?、?中國藥學(xué)雜志?、?中草藥?、?中藥材?等國內(nèi)外期刊上發(fā)表文章25篇,包括SCI論文10篇;參編專著2部,參編實(shí)驗(yàn)指導(dǎo)書3部;申請發(fā)明專利4項(xiàng),包括國際專利1項(xiàng)。參加學(xué)術(shù)團(tuán)體任職情況:國家自然科學(xué)基金同行評議專家,廣東核磁共振學(xué)會成員,?NaturalProductResearch?審稿專家。
科研成果
主要研究方向:天然藥物活性成分的生物合成和生物轉(zhuǎn)化
近三年主持及承擔(dān)的項(xiàng)目:項(xiàng)目名稱 | 起止時(shí)間 | 下達(dá)任務(wù)單位 | 經(jīng)費(fèi)(萬元) | 課題組排名 |
新型誘導(dǎo)子青蒿酸對長春花培養(yǎng)物中生物堿合成的誘導(dǎo)與代謝調(diào)控機(jī)制研究 | 2012-01-01--2014-12-31 | 國家自然科學(xué)基金 | 22 | 1 |
基于銀杏干細(xì)胞培養(yǎng)體系的海松二烯生物合成銀杏內(nèi)酯及其代謝調(diào)控研究 | 2014-01-01--2016-12-31 | 廣州市珠江科技新星 | 30 | 1 |
新型誘導(dǎo)子青蒿酸對長春花生物堿誘導(dǎo)及調(diào)控機(jī)制研究 | 2011-10-10--2012-10-31 | 廣東省自然科學(xué)基金基金 | 3 | 1 |
基于植物干細(xì)胞培養(yǎng)體系的喜樹堿生物合成及其代謝調(diào)控研究 | 2012-01-01--2013-12-31 | 暨南大學(xué)培育與創(chuàng)新基金 | 10 | 1 |
新型誘導(dǎo)子青蒿酸對長春花細(xì)胞中生物堿合成的誘導(dǎo)與代謝調(diào)控機(jī)制研究 | 2011-01-01--2011-12-31 | 暨南大學(xué)培育與創(chuàng)新基金 | 2.5 | 1 |
展開表格近年發(fā)表論文情況:1.Novel biotransformation processes of dihydroartemisinic acid and artemisinic acid to their hydroxylated deri-vatives by two plant cell culture systems. Process Biochemistry, 2010, 45: 1652-1656.(SCI,第一作者)
2. Enhancementofvindolineandvinblastineproductioninsuspension-culturedcellsofCatharanthusroseus by artemisinicacidelicitation.WorldJMicrobiolBiotechnol.publishedonline,2013,6:DOI10.1007/s11274-013-1432-z.(通訊作者)
3.Two new compounds from transgenicPanax quinquefolium. Fitoterapia, 2010, 81: 339-342.(SCI, 第一作者)
4.A new ceramide from transgenic crown galls ofPanax quinquefolium. Chinese Chemical Letters, 2009, 20: 447-449.(SCI,第一作者)
5.Three sesquiterpene compounds biosynthesized from artemisinic acid using suspension-cultured cells ofAverrhoa carambola. Natural Product Research, 2012, 26(15): 1388-1394.(SCI,第二作者)
6. Biotransformation of paeonol and emodin by transgenic crown galls ofPanax quinquefolium.Applied Bioche-mistry and Biotechnology, 2010, 160: 1301-1308. (SCI,第三作者)
7.Biotransformation of eugenol by transgenic crown galls ofPanax quinquefolium and cell suspension cultures ofNicotiana tabacum. World Journal of Microbiology and Biotechnology, 2010, 26: 1201-1205.(SCI,第三作者)
8.Stereo and region-selective biosynthesis of two new dihydroartemisinic acid glycosides by suspension-cultured cells ofArtemisia annua. Pharmacognosy Magazine, accepted on 21/Feb/2013. (SCI,第一作者)
9.Biosynthesis pathways of ginkgolides. Pharmacognosy Reviews, accepted on 09/Jan/2013. (SCI,第二作者)
10. ANewAntiproliferativeandAntioxidantPeptideIsolatedfromArcasubcrenata.Marinedrugs,2013, 11:1800-1814.(SCI,第四作者)
11.Impact of artemisinic acid on the growth and catharanthine accumulation in Catharanthus roseus cell cultures. Journal of Medicinal Plants Research, 2012, 6(10): 2019-2028. (共同第一作者)
12.Jianhua Zhu, Wei Wen, Yanshan Hu, Yu Tang, Rongmin Yu: Hydroxyl Octadecenoic Acids Biosynthesized by Crown Galls of Panax quinquefolium Induced by Artermisinic Acid (in English). Journal of Chinese Medicinal Materials. 35(6): 869-872. (第一作者)